TGF ß
A direct R-Phycoerythrin ( P E ) conjugated antibody applicable for the detection of TGF - ß by flow cytometry.
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Special features
 Detection of intracellular TGF-ß1 Direct conjugated antibody Complete intracellular detection protocol included Crossreacts with Human, Cow, Sheep and Pig Overview TGF-ß1, a member of the cytokine family, is multifunctional and regulates many aspects of cellular processes, such as proliferation, differentiation, adhesion, and apoptosis. TGF-ß1 plays an essential role in the development and homeostasis of virtually every tissue in organisms ranging from fruit flies to humans. Defects in TGF-ß1 signaling pathways are linked to major disease processes, including carcinogenesis, atherogenesis, fibrosis and autoimmunity.
To understand the various biological responses mediated by TGF-ß1 and its role in the control of basic cell fate decisions, a major goal is to define and characterize the responding signaling pathways and transcriptional targets. Use of different (animal) models in these studies emphasizes the availability of a ‘universal’ TGF-ß1 marker.
Currently, TGF-ß-responses were assayed using ELISA techniques. However, recognition and characterization of the different cell types that express TGF-ß1 is not possible. To meet these requirements, IQ Products developed an R-PE conjugated antibody that, besides a high inter-species cross reactivity, allows for the specific flowcytometric detection of TGF-ß1 in, for example, the pathogenesis of:
Malignant diseases Chronic inflammatory diseases Degenerative and autoimmune diseases |
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